Anseth

CU Boulder postdoc earns biomedical fellowship for intestine research

Anonymous — Wed, 13 Mar 2024 22:41:20 +0000

CU Boulder postdoc earns biomedical fellowship for intestine research Anonymous (not verified) Wed, 03/13/2024 - 16:41

Susan Glairon

Photo caption: An organoid patterned into desired shape using engineered biomaterial. Cell boundary is in green with magenta nuclei.

Kaustav Bera, a postdoctoral researcher in the Department of Chemical and Biological Engineering, was awarded a three-year postdoctoral fellowship from the Helen Hay Whitney

Foundation, which supports career growth of young scientists engaged in basic biomedical research.

The highly prestigious and very selective fellowship—less than 5 percent of applications are awarded—will support Bera’s postdoctoral training in studying the body’s maintenance of the gut epithelium, the inner lining of the gastrointestinal tract. The fellowship provides Bera, a member of CU Boulder’s Anseth Research Group, with a combined stipend of $220,500 over three years along with a $1,500 annual research allowance.

“I am honored to have received this fellowship and grateful for the trust the scientific committee has shown towards my scientific proposal,” Bera said. “Besides the financial benefits from the award, I am excited to be associated with this prestigious scientific community of past awardees, scientific advisory committee members and biomedical research luminaries, some of whom have been my research role models.”

Bera received his PhD in chemical and biomolecular engineering in 2022 from Johns Hopkins University. At CU Boulder he studies how the shape and function of the gut epithelium, a single layer of cells that plays a crucial role in nutrient absorption and secretion of digestive enzymes, is maintained. This layer also acts as a barrier to protect against harmful substances.

In a healthy state, intestinal stem cells frequently divide and regenerate to maintain the integrity of the epithelium in a highly controlled manner. But irregularities can lead to various diseases, including irritable bowel syndrome and colon cancer, Bera said.

Utilizing innovative biomaterial-based platforms developed in the laboratory of Distinguished Professor Kristi Anseth, Bera aims to gain deeper insights into how different factors precisely regulate the epithelial composition. He also collaborates with Associate Professor Peter Dempsey from the University of Colorado Anschutz Medical Campus to further develop three-dimensional models known as organoids which are derived from stem cells or tissue samples and mimic the function of organs or tissues in a laboratory setting.

“At the completion of this research, we should have a clearer understanding of how certain intestinal diseases can be better managed,” Bera said.

Kaustav Bera, a ChBE postdoctoral researcher, was awarded a three-year postdoctoral fellowship from the Helen Hay Whitney Foundation. The fellowship will support Bera’s postdoctoral training in studying the body’s maintenance of the gut epithelium.

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An organoid patterned into desired shape using engineered biomaterial. Cell boundary is in green with magenta nuclei.

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An organoid patterned into desired shape using engineered biomaterial. Cell boundary is in green with magenta nuclei.

Kristi Anseth selected as 2023 Outstanding Postdoc Mentor of the Year

Anonymous — Fri, 15 Sep 2023 16:05:49 +0000

Kristi Anseth selected as 2023 Outstanding Postdoc Mentor of the Year Anonymous (not verified) Fri, 09/15/2023 - 10:05

Distinguished Professor Kristi Anseth was selected by the Office of Postdoctoral Affairs as the 2023 Outstanding Postdoc Mentor of the Year Award recipient.

Anseth's nomination for this recognition was made by postdoctoral scholars in the Anseth Research Group, including Alex Khang, Della Shin, George Tseropoulos, Kaustav Bera, Michael Blatchley and Monica Ohnsorg. Their nominations highlighted Anseth's exceptional leadership in mentoring more than 45 postdoctoral researchers, with 20 of them now serving as faculty members at top universities. The group also praised Anseth's “incredible empathy and understanding” with personal matters requiring time away from the lab, as well as her commitment to fostering a healthy work/life balance.

Anseth will be recognized September 20 during a celebration breakfast for National Postdoc Appreciation Week.

Distinguished Professor Kristi Anseth was selected by the Office of Postdoctoral Affairs as the 2023 Outstanding Postdoc Mentor of the Year Award recipient.

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ChBE PhD student publishes paper that will help improve studies of intestinal tissue

Anonymous — Thu, 09 Feb 2023 21:03:57 +0000

ChBE PhD student publishes paper that will help improve studies of intestinal tissue Anonymous (not verified) Thu, 02/09/2023 - 14:03

Chemical and Biological Engineering PhD student Max Yavitt is the lead author on a new paper in Science Advances that focuses on human intestinal tissue research. The work could allow researchers to control the shape of intestinal tissue cultured outside of the body – allowing for better study of physical changes due to injury or illness.

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Kristi Anseth named one of best female scientists in the world by Research.com

Anonymous — Tue, 15 Nov 2022 16:17:30 +0000

Kristi Anseth named one of best female scientists in the world by Research.com Anonymous (not verified) Tue, 11/15/2022 - 09:17

Kristi Anseth, distinguished professor and Tisone professor of chemical and biological engineering, was ranked 83 of "best female scientists in the world" by Research.com. Anseth is known for her research in tissue engineering.

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ChBE students make an impact at NCSU Future Leaders in Chemical Engineering symposium

Anonymous — Tue, 07 Dec 2021 07:00:00 +0000

ChBE students make an impact at NCSU Future Leaders in Chemical Engineering symposium Anonymous (not verified) Tue, 12/07/2021 - 00:00

Jonathan Raab

Students gathered for a photo after the symposium. Courtesy NCSU.

Students from the Department of Chemical and Biological Engineering presented their research as part of the competitive NC State University Future Leaders in Chemical Engineering symposium this past October. Three students from the department were recognized as awardees.

Michael Bibbey

Michael “Griff” Bibbey is a senior chemical and biological engineering student working as an undergraduate researcher in the Cha Group. Bibbey presented his research on engineering novel photoactive protein therapeutics for improved chemotherapy efficiency and the inhibition of tumor growth.

“I was heavily involved in demonstrating the ability of our protein to slow the growth and spread of breast cancer,” Bibbey said. “This research is a big step in evaluating the efficacy of our modality, but more broadly it gives some important insight to the way bioconjugates may be able to induce cellular quiescence — a state of reversible growth arrest — in cancers.”

Michael "Griff" Bibbey

As an attendee of the symposium, Bibbey enjoyed the opportunity to connect with his fellow undergraduate researchers and established faculty leaders in the fields of colloids, protein and pharmaceutical engineering and soft matter physics.

“I got to meet the brilliant young researchers who will be my colleagues for the rest of my career and made some great connections,” he said.

Bibbey plans on continuing his research with the Cha Group on a tissue engineering project for his senior thesis. He is working alongside Sanheli Ganguly, a postdoctoral researcher, to develop a rapid, facile method for the DNA-mediated assembly of tissues. He recently co-authored a paper in Biotechnology & Bioengineering.

Bibbey will pursue a PhD in chemical engineering to enter a career in nanomedicine.

"Griff has shown tremendous potential as both a researcher and educator," said David Clough Professor Jennifer Cha. “Over the past year or so, he has not only been doing experiments in my group which has led to him being a coauthor on a recently published article, he has been awarded several prestigious fellowships to intern at places such as Proctor and Gamble. Griff has been helping extensively in the classroom as a course assistant and TA. I see a very bright future for him in graduate school and beyond.”

Shambojit Roy, a graduate student in the Cha Group, also shared praise for Bibbey.

“I have been mentoring Griff for the past year, and he is extremely enthusiastic and has a great attitude towards research,” Roy said. “He's a quick learner and has always shown interest in learning new things. I think he will do exceedingly well in graduate studies and research in general.”

Carrie Bishop

Carrie Bishop is a senior chemical and biological engineering student working in the Anseth Research Group, which focuses on using biomaterial scaffolds in cell and tissue engineering.

For her presentation, she described the lab’s research into the cardiac disease Aortic Valve Stenosis (AVS) that causes abnormal blood flow through the heart.

Carrie Bishop

“A main part of the disease progression of AVS is that cells on the aortic valve undergo a phenotypic change that results in the valve becoming more stiff and calcific, but it is not fully understood why these changes occur,” Bishop said. “The Anseth Group has previously shown that we can use hydrogels — a type of biomaterial with a controllable stiffness — to better mimic healthy and diseased cellular environments.”

Bishop said that this causes cells to undergo phenotypic change. The group investigated the epigenetic mechanics that appeared to control how the cells changed.

“I analyzed genomic sequencing data for RNA expression and the accessibility of distinct regions of chromatin to narrow down what genes might be causing the changes in cell expression based on changes in the mechanical environment,” Bishop said. “As a result of the overlaps between the differential expression of genes from healthy versus disease-like cells, we found four genes and numerous transcription factors that are implicated in this cellular transition, and therefore may be implicated in AVS.”

The group is currently investigating the in vitro effects of those genes, which may result in pharmaceutical and therapeutic treatments that would obviate the need for invasive surgery procedures.

“Through more than two years in my lab, Carrie has proven herself to be relentlessly curious, independent and unafraid to tackle new challenges,” said Distinguished Professor Kristi Anseth.

“Carrie is extremely motivated about doing research,” said Dilara Batan, Bishop’s graduate student mentor. “She is very self-motivated in learning new techniques and actively seeks additional challenges. She's well on her way to becoming an independent researcher.”

Bishop greatly enjoyed the symposium experience.

“The symposium was fantastic. I was able to learn about a variety of other areas in chemical engineering research outside of CU Boulder,” Bishop said. “In addition to strengthening my presentation skills, it was great to be at an in-person poster session again, although it took a little getting used to.”

Bishop thanked her mentors for their guidance, including Benjamin Carberry, Cierra Walker, Dilara Batan and Kristi Anseth.

Bishop is working on a senior thesis project with the Anseth Research Group, as well as applying to graduate schools and exploring employment opportunities in the bioengineering and computational biology sectors.

Cyrus Haas

Cyrus Haas is a senior chemical and biological engineering student working in the Whitehead Research Group. Haas presented research on a new method to identify SARS-CoV-2 escape mutations.

Cyrus Haas

“An escape mutation occurs when SARS-CoV-2 mutates, preventing the immune defenses that humans have developed from fighting back against the virus,” Haas said. “This can have a significant impact on vaccine and monoclonal antibody treatment efficacy. The rise of new SARS-CoV-2 variants like Delta show that variants with escape mutants are already seen in circulation.”

Haas said these variants can lead to higher infection rates and more severe cases of COVID-19.

“The research provides a complete experimental pipeline for identifying potential escape mutations before they are seen in circulation,” Haas said. “My specific work focused on developing software that could be used to compile experimental DNA sequencing data and run a statistical analysis to identify the potential escape mutations.”

“Cyrus is an incredibly bright and talented undergraduate,” said Associate Professor Timothy Whitehead. “He has already been a co-author on two published papers, which is an outstanding achievement for an undergraduate researcher. He has been able to make contributions in my lab both computationally as well as experimentally.”

Haas credited Irene Francino-Urdaniz for leading the research project and developing the experimental pipeline. He also thanked postdoctoral associate P.J. Steiner for help with writing the software and Whitehead for his guidance and mentorship.

“This was the first in-person setting where I was able to share the research I worked on with other peers, graduate students and faculty,” Haas said.

“There were many other students from the symposium that were presenting important research and it was a great place to meet other chemical engineers from around the country. I’m excited for the opportunity to stay connected with these peers and potentially work with them in the future.”

Haas is applying to graduate school to pursue a PhD in chemical and biological engineering, with a focus on protein engineering and synthetic biology.

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Kristi S. Anseth Receives AIChE’s Founders Award for 2021

Anonymous — Tue, 09 Nov 2021 21:18:47 +0000

Kristi S. Anseth Receives AIChE’s Founders Award for 2021 Anonymous (not verified) Tue, 11/09/2021 - 14:18

The recipient of the 2021 Founders Award is Kristi S. Anseth, Distinguished Professor and Tisone Professor of Chemical and Biological Engineering at the University of Colorado at Boulder (CU-Boulder). Dr. Anseth is being lauded for her “seminal contributions to the application of foundational aspects of chemical engineering to the design of advanced biomaterials, hybrid medical devices, and bionanoscale-based processes.”

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