Innovative use of the听C.elegans听model in diverse research fields
The Xue Laboratory was founded in the fall of 1997 with the express goal of studying the genetic and molecular mechanisms of听programmed cell death. The laboratory has made numerous important contributions not just to the field of programmed cell death, but has extended its reach to several diverse research fields. The Xue Lab has recently redirected its focus to four major research areas: study of the genetics and molecular mechanisms that establish and maintain听phospholipid asymmetry, characterization of the mechanisms and physiological significance of听maternal mitochondrial inheritance听during early development, analysis of听radiation-induced bystander effects (RIBE)听and its importance and applications in radiotherapy, and the use of听C. elegans听as an animal model to study various听human disease听and to perform听drug discovery. In these pursuits the lab has very recently made significant contributions to our understanding of the mechanism of action of Hepatitis B Virus X protein, made key discoveries in the field of phosphotidylserine asymmetry and externalization (see below video). Beyond these contributions the Xue Lab has also made important discoveries in characterizing the chromosome fragmentation process during apoptosis, including the identification of the caspase-dependent conversion of the dicer ribonuclease into a deoxyribonuclease and multiple apoptotic nucleases involved in the process. We hope to continue to provide contributions to a wide array of research fields. For more detailed information about the projects studied by the Xue Lab, please see our听Projects听辫补驳别. To contact the Xue Lab, please proceed to the听Contact听辫补驳别.
Analysis of activation, execution, and engulfment in听颁.听别濒别驳补苍蝉听embryo apoptosis
A secreted Annexin GFP sensor labels surface-exposed PS during apoptosis.
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Analysis of paternal mitochondria elimination in a wild-type C. elegans embryo
MitoTracker Red-stained paternal mitochondria are eliminated during early embryogenesis.